East China Normal University (Kwok)

The dataset includes anatomical, resting-state, and magnetic resonance spectroscopy data from 4 monkeys.

Usage Agreement

Creative Commons – Attribution-NonCommercial Share Alike (CC-BY-NC-SA)- Standard INDI data sharing policy. Prohibits use of the data for commercial purposes.

Species

Macaca mulatta

Sample Description

• Sample size: 4
• Age distribution: 32-45 months
• Weight distribution: 3.70-4.68 kg
• Sex distribution: All male

Click here for the full sample description (.csv)

Phenotypic Assessments

Scan Procedures and Parameters

Ethics approval: Approved by University Committee on Animal Research Protection of East China Normal University.

Animal care and housing: Housed singly or in pairs, with automatically regulated lighting; monkey chow and fruit given twice a day (350g in total) and water available ad libitum.

Any applicable training: Monkeys were trained to watch videos and respond on touch screen apparatus.

Scanning preparations

Anesthesia procedures:

1. Atropine was applied via subcutaneous injection 20min before anesthesia (dosage = body weight * 0.05mg/kg).
2. Zoletil^TM 50# was used via subcutaneous injection (dosage = body weight * 0.1ml/kg)
3. After the monkeys were head-fixed on the Stereotaxic, 0.3ml Zoletil^TM 50# was injected.

Time between anesthesia and scanning: 30 min

Head fixation: Kopf frame and ear bars

Position in scanner and procedure used: Sphinx positon in MRI stereotaxic apparatus

Contrast agent: None

During scanning

Physiological monitoring: Electrocardiography (ECG), respiration monitoring

Additional procedures: Mechanical ventilation. Body temperature kept warm with blanket. Food control 12 hours prior to anesthesia.

Scan sequences

• Scanner type: 3T horizontal bore scanner (Siemens Trio)
• Head coil: Surface coil
• Optimization of the magnetic field prior to data acquisition: Manual shimming
• Resting-state:
  • Voxel resolution: 1.9 x 1.9 x 1.8mm
  • TE: 44ms
  • TR: 3000ms
  • TA: 8:06
• Diffusion-weighted (DTI):
  • Voxel resolution: 1.8 x 1.8 x 2.5mm
  • TE: 113ms
  • TR: 4600ms
  • Flip angle: 90°
  • Number of directions: 30
• Structural:
  • T1
  • Voxel resolution: mm
  • TE: 77ms
  • TR: 3000ms
  • Flip angle: 15°
  • T2
  • Voxel resolution: 0.5 x 0.5 x 1.0mm
  • TE: 3.38ms
  • TR: 2200ms
  • Flip angle: 120°
• Magnetic Resonance Spectroscopy:
  • Voxel resolution: 10 x 10 x 10mm
  • TE: 30ms
  • TR: 2000ms
  • TA: 8:06
  • Flip angle: 90°
  • Averages: 256

Personnel

• Sze Chai Kwok^1,2,3
• Yong-di Zhou⁴

¹Shanghai Key Laboratory of Brain Functional Genomics, School of Psychology and Cognitive Science, Key Laboratory of Brain Functional Genomics (Ministry of Education), East China Normal University, Shanghai 200062, China
²Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai 200062, China
³NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai 200062, China
⁴Krieger Mind/Brain Institute, Department of Neurosurgery, Johns Hopkins University, Baltimore, MD 21287, USA

Acknowledgements

Data were acquired at the Shanghai Key Laboratory of Magnetic Resonance at ECNU. Data were collected and deposited by Qun Ye, Lei Wang, Yudian Cai, and Shuzhen Zuo.

Funding

Ministry of Education of PRC Humanities and Social Sciences Research Grant 16YJC190006, STCSM Shanghai Pujiang Program 16PJ1402800, STCSM Natural Science Foundation of Shanghai 16ZR1410200, and National Key Fundamental Research (973) Program of China Grant 2013CB329501

Downloads

Click here to download the data. Users will first be prompted to log on to NITRC and will need to register with the 1000 Functional Connectomes Project website on NITRC to gain access to the PRIME-DE datasets.